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Fig. 5. Decreased interdigital cell death results in soft tissue syndactyly of the hindlimbs in X{alpha}af1o/Xß mutants. Comparison of (a) cell death assessed by Nile Blue Sulfate staining, (b) expression of stromelysin-3 assessed by in situ hybridization and (c) morphology, between E14.5 (a,b) and adult (c) wild type (WT) and X{alpha}af1o/Xß mutants. PNZ, posterior necrotic zone; I-V, digit one to five. The arrows point to the two interdigital regions, which are the most severely affected in adults.