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Fig. 1. Alternative Wnt signal transduction pathways. (A) The canonical Wnt signal transduction pathway, which functions in many tissues. (B) The signal transduction cascade that Wnt7a uses to control axonal remodelling in the developing mouse brain. (C) Frizzled patterns cell polarity during Drosophila eye development through a JNK cascade. (D) The Wnt5a class of ligands exerts its effects via a Ca2+-dependent signal transduction pathway.