Fig. 3. Increased OP cell migration on TN-C-null astroglial ECM substrate. Measurements of rat OP migration from the edge of an agarose drop show that after 1 and 2 days, the distance moved by the cells is greater on the TN-C-null astroglial substrate than on the wild-type astroglial substrate (Student’s t test: **P<0.01, ***P<0.001). Note that the addition to the substrate of purified TN-C at 40 µg/ml before the assay does not reduce OP cell migration on the TN-C-null substrate. Results shown represent mean±s.e.m. from three to six independent experiments (WT, wild type; -/-, null).