Fig. 5. Reduction in cell proliferation of OPs in the CNS of TN-C-null mice with a 129 genetic background. BrdU (green)/NG2 (red) double staining experiments at P7, in the SVZ (A) and in the cortex (B) of an heterozygous animal and in the cortex of a TN-C-null homozygous animal (C). Very few BrdU-positive cells were NG2 positive in the SVZ, while in the cortex, the OP (NG2-positive) population represents about a third of the proliferative (BrdU-positive) cells (B). Note that in TN-C-null homozygous animals (C), fewer double-stained cells were found in the cortex in comparison with heterozygous littermates (B). Scale bar: 50 µm.