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Fig. 1. Pathway of sphingomyelin degradation. The pathway reflects studies in animal cells. To date the genes for the S-1-P lyase (Accession Number, AF233610), two sphingosine kinases (cDNA clone SLG787 – Accession Numbers, AU061963 and AU039939, and cDNA clone SLE414 – Accession Number, AU061484), two sphingosine-1-P phosphatases (cDNA clone SSE389 – Accession Numbers, AU072386 and AU037870, and cDNA clone SSC687 – Accession Number, C85040) and a ceramidase (Accession Number, AAB69633) have been identified in Dictyostelium.