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Fig. 5. smu mutant embryos have residual Hedgehog function provided by maternal Smoothened. shh mRNA increases expression of nkx2.2 after injection into wild-type (B) and smu mutant (D) embryos compared with uninjected wild-type (A) or smu mutants (C). Injection of shh and twhh morpholinos into smu mutants decreases residual nkx2.2 expression (F) compared with uninjected mutants (E). Side views, anterior towards the left; (A-D) two-somite stage; (E, F) Prim-6 stage. Scale bar: 100 µm.