Fig. 7. Alkaline phosphatase-expressing LGE cells in 3-week-old animals. (B,D,E) Two to three fused photographs taken in different focal planes. (A) LGE cells disperse throughout the striatum and migrate ventrally into the olfactory tubercle (ot). Many labeled axons crisscross the ventral pallidum (vp). Notice that this distribution is complementary to the distribution of MGE cells (Fig. 3). No cells are detected in the septum (sep) and only rarely in the neocortex. (B) LGE cells in the striatum differentiated into medium spiny neurons. (C) Projecting axons were found among others in the medial globus pallidus. (D) The few LGE-derived neurons that migrated into the neocortex differentiated into aspiny neurons. LGE cells migrated to the olfactory bulb and differentiated into interneurons in the granule cell layer (gcl) and glomerular layer (gl). (E) Immature neurons were observed in the rostral migratory stream (rms). (F) LGE cells in the olfactory tubercle differentiated into bi-tufted spiny neurons with processes reaching the surface of the brain.