Fig. 5. Fgf receptor and Bmp7 signaling cooperate in lens development. All panels show Hematoxylin and Eosin stained sections of P0 mouse eyes. (A) Wild-type eye. (B) Tfr7/Tfr7 mouse eye with persistent lens stalk (red arrowhead). The blue arrow indicates the eyelid suture. (C,D) Bmp7^-/- eyes showing the range of possible phenotypes manifesting as microphthalmia (C) and anophthalmia (D). Only the eyelid suture (blue arrow) is recognizable in the case of anophthalmia (D is twice the magnification of other panels). This can be compared with the eyelid suture in B (blue arrow). (E) Eye section from Tfr7/Tfr7, Bmp7^+/- mouse showing the typical phenotype featuring failure of lens vesicle closure and separation (red arrowhead), and extrusion of eosinophilic fiber cell material into the conjunctival sac (black arrows). (F) Eye section from a second Tfr7/Tfr7, Bmp7^+/- mouse showing failure of lens vesicle closure and separation (red arrowhead) and extrusion of fiber cell material into the vitreous (arrowheads). (G,H) Two different examples of eye sections from Tfr7/Tfr7, Bmp7^-/- mouse eyes showing the disproportionate effects on lens development compared with Bmp7^-/- mouse eyes (C). In these cases, the lens (arrowheads) is disrupted (G) and smaller than observed in any other genotype (G,H).