Fig. 6. Disruption of the horizontal cell array 24 hours after treatment with oligo antisense to tau at P6. (A,B) The regular horizontal cell array (A, P6) is turned into an irregular distribution of cells (B) 24 hours after intraocular injections of 25 µM PP oligo RT11 antisense to tau (P7). Scale bar: 20 µm. (C,D) Array disorganization is quantified by the irregular distribution of Delaunay segments (C) and depth scatter (D) (symbols represent examples of treated cases, the grey curves represent normal cases). The treated cases in D are illustrated upside-down to facilitate comparison with the normal controls (grey curve). Bootstrap analysis confirms the statistically significant difference between the treated and the normal datasets.