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Fig. 2. The gross morphology of Hoxa7-Gcm1 transgenic mice. (A,B) Lateral views of E12.5 wild-type (A) and transgenic (B) embryos. The arrow in B indicates spina bifida in the transgenic embryo. (C,D) Lateral and posterior aspect of a transgenic E16.5 embryo revealing a subcutaneous neural plate-like structure (arrow). (E,F) Posterior aspects of 1-week-old wild-type and transgenic littermates. Scarring and necrosis is evident in the transgenic pup (arrow).