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Fig. 4. Decreased liver IGF1 expression and circulating IGF1. (A) Levels of circulating IGF1 in control (CTRL males n=8; CTRL females n=4) and in B4B2A5m mice (TG males n=8; TG females n=5). Circulating IGF1 is significantly decreased in transgenic mice of both sexes (male: P<0.0032; female: P<0.018). (B) Northern blot analysis of liver IGF1 mRNA expression. IGF1 mRNA signal (two transgenic B4B2A5m and two control mice) was normalized with a GAPDH probe. The histogram shows that, compared with control, IGF1 mRNA levels in transgenic animals are halved (P<0.05).