Development -- Suh et al. 129 (2): 329 Figure IG6

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Fig. 6. Pitx1 and Pix2 have functional overlaps in pituitary ontogeny. Histological examinations of double mutants carrying Pitx1^– and Pitx2^neo alleles show the normal formation of Rathke’s pouch in all genotypes (A-C), but not in Pitx1^–/–;Pitx2^neo/neo mice at E12.5 (D). Note that Rathke’s pouch in Pitx1^–/–;Pitx2^neo/neo mice does not expand (D). Immunoreactive LHX3 is present all genotypes (E-H).