Development -- Byrd et al. 129 (2): 361 Figure IG5

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Fig. 5. Morphology of Ihh^–/– yolk sacs. (A) 10.5, 11.5 and 12.5 dpc Ihh mutant yolk sacs display vascular defects. Ihh^–/– yolk sacs contain fewer and smaller vessels and undergo suboptimal vascular remodeling compared with Ihh^+/– yolk sacs. Scale bar: 1mm. (B) Whole-mount PECAM staining in 11.5 dpc yolk sacs. Ihh^+/– vessels appear uniform in diameter and well organized. Note the small vessels (arrow) and flattened morphology (arrowhead) in the Ihh^–/– yolk sac compared with the similar junction in the Ihh ^+/– yolk sac. Scale bar: 500 µm.