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Fig. 2. Deficiency of collagen IV expression causes a variable degree of growth retardation in embryos at E9.5 (A), E10.5 (B) and E11.5 (C). The genotypes of representative littermates are indicated (+/+, +/–, –/–). Embryos at E11.5 show bleeding from the heart and dilation of blood vessels (arrows). Scale bars: 100 µm.