Fig. 2. cv-c encodes RhoGAP88C. (A) Genomic map depicting part of the 88B-88C interval of the third chromosome (centromere is towards the left). All known and predicted genes in the region are shown; those drawn above the line are transcribed left to right, whereas those below are transcribed right to left. Small nucleotide polymorphic (SNP) loci used for mapping are indicated with orange lollipops. The P-element inset l(3)06951 is represented by the blue triangle. Two transcription units without predicted translation products (green), are indicated by their EST clot numbers. (B) The Cv-c protein is 1017 amino acids in length and contains three evolutionarily conserved domains: the N-terminal sterile motif (SAM) (green), the GAP domain (blue) and the C-terminal START domain (orange). (C) Comparison between fly Cv-c and its homologues: human deleted in liver cancer 1 and 2 (DLC1 and DLC2); rat p122; mouse seriologically defined in colon cancer antigen 13 (SDCCA13); and worm gut-on-exterior interacting protein 1 (GEI-1). Percentage of amino acids that are identical in fly Cv-c and in each of the homologues is shown for the SAM (green), GAP (blue) and START (orange) domains. Molecular lesions for cv-c^C524 [R369stop (black asterisk)], cv-c⁷ [R601Q] and cv-c^M62 [Q666stop (blue asterisk)] are indicated.