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Fig. 2. Gross morphological and histological phenotype of LAP-tTA/TRE-VEGFR2T newborn mice. (A) A dark-red appearance distinguishes the LAP-tTA/TRE-VEGFR2T mutant livers from controls. Dox suppresses this phenotype. (B,C) Body weight and liver/body weight ratios of LAP-tTA/TRE-VEGFR2T newborns are comparable to LAP-tTA controls. (D) Western blotting with an anti-albumin antibody. (E) Insignificant reduction in hepatocyte proliferation in mutant livers by PCNA staining. (F) No significant difference in apoptosis. The number of proliferating cells (E) or apoptotic cells (F) is per 40 x microscopic field. Error bars represent the s.d.