Fig. 9. The Wnt4^–/– nephrogenic phenotype. (A,C,E,G) Control; (B,D,F,H) Wnt4^–/–. Metanephroi from E18.5 control (A) and Wnt4^–/– (B) embryos. Wnt4^–/– metanephroi develop few nephrons (a nephron-like structure is shown in B, inset). (C-H) Wnt4^–/– metanephroi also develop few foci of Fgf8 expression (C-E), and express no Lim1 in induced MM (H, compare with G). Arrows and arrowheads indicate MM and UB expression domains, respectively. Scale bar in H: 250 µm.