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Fig. 3. Oikopleura orthologs of vertebrate placode-marking genes. (A) Gene structures for five larvacean genes (red, Eya domain; black, homeodomain; blue, Six domain; green, intron unique to larvacean Six3/6 duplicates). (B) Topologies of neighbor-joining gene phylogenies of aligned protein sequences are consistent with assignment of Oikopleura genes to Eya, Pitx, Six1/2 and Six3/6 orthologies.