Fig. 1. (A) The predicted amino acid sequence of AprA. The amino acid sequences from tryptic peptides of AprA are shown by grey boxes. The SignalP program predicted that amino acids 1-18 are a signal sequence, with a maximum cleavage site probability (0.933) between amino acids 18 and 19. Asterisks indicate potential N-and O-linked glycosylation sites. A double underline indicates a potential ATP-GTP binding site. The broken underline indicates the region with some similarity to human proteins. (B) The partial sequence of AprA (top line) compared with a short region of similarity in three different human ESTs.