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Fig. 5. Cessation of neuronal lineage development in mutant OE. (A) In situ hybridization on serial coronal sections through E10.5 nasal pit. No Fgf8 ex2,3 is detected in mutant. (B) In situ hybridization on serial coronal sections of E12.5 Type A mutant. Arrowhead indicates region of Sox2-expressing epithelium in sections hybridized with other probes. (C) In situ hybridization on horizontal serial sections of E14.5 Type B mutant. Arrow indicates apparent OE remnant. (D) In situ hybridization on horizontal sections of E17.5 Type B mutant. Arrowheads indicate presumptive remnant of OE. NP, nasal pit; MNP, medial nasal process; VG, Vth ganglion; OC, oral cavity; T, tongue; VNO, vomeronasal organ; FB, (presumptive) forebrain; NR, neural retina; S, nasal septum. Scale bars: 200 µm.