Fig. 2. Notch suppresses the activity of Armadillo^S10. Wing pouch region of third larval instar wing discs showing the response of high (Senseless, Sens) and low (Distalless, Dll) threshold targets of Wingless signalling to normal or ectopic activity of Armadillo. (A-C) Wild type. (A) Distalless expression; notice a slight elevation of the expression at the DV boundary. The white line indicates the approximate domain of dpp expression. (B) Senseless expression highlighting neural precursors that develop in response to high levels of Wingless signalling (Couso et al., 1993). (C) Merged image of A and B. (D-F) Wing pouch of a disc expressing Armadillo^S10 under the control of dppGAL4. (D) Distalless expression is now elevated and expanded over the AP boundary. (E) Senseless can be detected over a new domain along the AP boundary. (F) Merged image of D, E. (G-I) Wing pouch of a disc expressing Armadillo^S10 and TNotch under the control of dppGAL4. (G) The effects of Armadillo^S10 on Distalless are suppressed by TNotch, a reduction of wild-type levels is also observed. (H) The ectopic expression of Senseless induced by Armadillo^S10 is suppressed by TNotch. Notice also the reduction in the endogenous expression over the domain of TNotch expression. (I) Merged image of G and H.