Fig. 2. A skn-1-dependent transcriptional cascade. (A) Published expression patterns and regulatory relationships for four transcription factors and a differentiation gene involved in endoderm development. (B) Temporal expression patterns in wild type, pie-1(zu154) and mex-3(zu155); skn-1(RNAi) measured by microarray. med-1 and med-2 cannot be distinguished on the microarray.