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Figure 7


Fig. 7. Sens can synergize with proneural proteins on the UAS-tk-luc reporter in S2 cell transcription assays. (A) Schematics of the UAS-tk-luc reporter construct. (B) S2 cell transcription assays using UAS-tk-luc reporter. Sens expression alone does not have a significant effect on the basal expression of the UAS-tk-luc reporter. However, Sens is able to synergize with Sc and Ac. (C) E(spl)m7 strongly inhibits the expression induced by the Sc-Gal4DBD and the synergism between Sens and Sc-Gal4DBD. (D) When fused to Gal4DBD, Sens acts as a strong repressor on the UAS-tk-luc reporter. Ac and Sc fail to synergize with DNA-bound Sens.