Fig. 7. Ectopic expression of Mesp2 leads to skeletal malformations. Skeletal preparations of 18.5 dpc wild-type (A-D) and CAG-CAT-Mesp2; Mox1-Cre fetuses (E-H) stained with Alcian Blue and Alizarin Red. Lateral (A,E) and dorsal (B,F) views of whole skeletons are shown. Higher magnifications of the lumber region from wild-type (C,D) and double heterozygous fetuses (G,H) are also shown. The lack of pedicles of the neural arches could be observed in the double heterozygotes (G,H). The rib structure was also severely affected in the double heterozygotes (G,H). pd, pedicle; lm, lamina.