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Figure 7


Fig. 7. Cx43{alpha}1 perturbation alters the response of CNCs to Sema3a. (A) Timelapse images of Cx43{alpha}1+/+, Cx43{alpha}1-/- and CMV43 CNCs treated with Sema3a. Images were captured at 1-minute intervals over 20 minutes, with area of expansion indicated by green (positive flow) and area of contraction indicated in red (negative flow). The image on top represents the cell at the last time frame, with underlying cell outlines corresponding to preceding timelapse frames. (B) Positive and negative flows were decreased in wild-type, Cx43{alpha}1KO and CMV43 CNCs after Sema3a treatment, but the cell roundness was increased only in the wild-type CNCs (B). Error bars indicate s.e.m. *P<0.05, when compared with cells without Sema3A of same genotype.