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Figure 4


Fig. 4. Localization of developing hematopoietic stem cells (HSC)s in the mouse embryo. Immunohistochemistry of E10 Runx1-lacZ mouse embryo shows Runx1-lacZ-expressing cells (blue) are present in (A) the dorsal aorta and the adjacent mesenchyme (ventral, top left-hand corner), and (B) the yolk sac. Although not all Runx1-positive cells are HSCs, all developing HSCs and progenitors express Runx1 and are therefore postulated to reside within the Runx1-expressing cell population. Runx1-lacZ, blue; laminin, red. Arrows indicate Runx1-lacZ-expressing cells. Images provided by H.K.A.M.