Fig. 1. Comparison of the primary structure between TSKA and TSKB. (A) Schematic drawing of the primary structure of TSKA and TSKB. The leucine-rich repeats (LRRs) are indicated as circles. Cysteine residues are indicated by red bars. (B) Alignment of C-terminal Tsukushi cDNA and amino acid sequences. The 990-1309 (red) nucleotide sequence is deleted by degenerate 5' splicing, resulting in the production of TSKA from TSKB. (C) Schematic drawing for the generation of TSKA and TSKB isoforms by alternative 5' splicing of chick Tsukushi gene. The numbers on the top correspond to the nucleotide sequence in B.