Development -- Yamasaki et al. 133 (21): 4233 Figure IG10

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Fig. 10. Bile duct development and C/EBP ${alpha}$ . The portal environment induces suppression of C/EBP ${alpha}$ expression, which leads to downregulation of hepatocyte-specific genes and upregulation of Hnf6 and Hnf1b genes. The deposition of basal laminar components, expression of DBA- and SBA-binding sites, and suppression of HNF4 expression are not downstream of the action of C/EBP ${alpha}$ . Jag1 and Notch2 mRNA expression might be downstream of C/EBP ${alpha}$ . CK, bile duct-specific cytokeratin.