Fig. 7. Altered migration patterns of ventrally migrating neurons by loss of ephrin A5. (A,B) Altered migration pattern of olfactory cortex neurons in ephrin A5-deficient embryos. In the ephrin A5^+/– mice, the dorsally derived GFP-labeled neurons stop at the PSB (arrows in A). However, in ephrin A5 homozygous mutant embryos, the GFP-labeled neurons invaded the ventral part of the telencephalon (arrowheads in B). (C) Comparison of migratory distance of GFP-positive cells in between and ephrin A5^+/– and ephrin A5^–/– mice. In ephrin A5^–/– mice the number of GFP-positive cells was significantly increased in the area over 1200 µm distant from the injection point. Data are presented as percentage of the labeled cells in each area against the total number of labeled cells (mean±s.d. of three samples in each group). ^*P<0.05, ^**P<0.01. Scale bar: 500 µm.