Fig. 8. Expression of Fez and Arx is mutually independent. (A-D) Expression of ARX in Fez^+/– (A,C) and Fez^–/– embryos (B,D) at E12.5 (A,B) and E14.5 (C,D) was detected by immunofluorescence staining. ARX proteins are detected in the ganglionic eminence and the RMS to the olfactory bulb (OB). (E-H) Expression of Arx in Fez^+/– (E,G) and Fez^–/– embryos (F,H) at E16.5 (E,F) and P0 (G,H). Expression of ARX and Arx was not affected at the developmental periods examined. (I-L) Expression of Fez in wild-type control (WT, I,K), and Arx-deficient (Arx KO, J,L) embryos at E12.5 (I,J) and E14.5 (K,L). Expression of Fez in the olfactory epithelium (OE) is not affected in Arx-deficient embryos.