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Figure 2


Fig. 2. Fgf8{Delta}b-neo/{Delta}b-neo embryos have more severe defects than Fgf8{Delta}b/{Delta}b embryos. (A-D) Morphology and histology of murine wild-type (A,B) and Fgf8{Delta}b-neo/{Delta}b-neo (C,D) embryos at E7.5. (B,D) Hematoxylin and Eosin (H&E) analysis of sagittal sections of the embryos shown in A and B, respectively. Notice the mesodermal cells (arrowheads) accumulated at the primitive streak (brackets) in the Fgf8{Delta}b-neo/{Delta}b-neo embryo. (E,F) Lateral view of a wild-type embryo (E) and dorsal view of an Fgf8{Delta}b-neo/{Delta}b-neo embryo (F) at E8.5. (G-J) Morphology and histology of wild-type and Fgf8{Delta}b/{Delta}b embryos at E8.5. Arrowheads indicate the rough appearance of the amniotic membrane of Fgf8{Delta}b/{Delta}b embryos, compared with the control. (I,J) H&E analysis of sagittal sections of the embryos in G and H, respectively. PSM, presomitic mesoderm.