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Figure 4


Fig. 4. Fgf4 and Wnt3a are expressed in the primitive streak of murine Fgf8{Delta}b/{Delta}b, but not in Fgf8{Delta}b-neo/{Delta}b-neo, embryos at E7.5. (A) Expression of Fgf4 in embryos of indicated genotypes. (B-D) Expression of Wnt3a in wild-type (B), Fgf8{Delta}b/{Delta}b (C) and Fgf8{Delta}b-neo/{Delta}b-neo (D) embryos. Notice that the morphologically distinct node (arrowhead) is absent in Fgf8{Delta}b/{Delta}b and Fgf8{Delta}b-neo/{Delta}b-neo embryos. Arrows mark the mass of mesodermal cells, which is variable and tends to be smaller than that found in Fgf8{Delta}b-neo/{Delta}b-neo embryos, at the primitive streak of Fgf8{Delta}b/{Delta}b embryos at E7.5.