Fig. 5. Socs5^-/- mice exhibit accelerated mammary gland development. (A) Whole mounts and H&E-stained sections of inguinal mammary glands from wild-type (WT) and Socs5^-/- mice at day 10 and 15 of gestation. (B) The number of alveoli was scored in H&E images from wild-type and Socs5^-/- mice at 40x magnification and the area of the fat pad was measured using ImageJ software. The number of alveoli/mm² was calculated and the percentage relative to wild-type was plotted. (C) Whole mounts and H&E staining of inguinal mammary glands from NOD and NOD-SCID mice at day 5 of gestation. (D) The number of alveoli/mm² from wild-type, NOD, NOD-SCID, Stat6^-/- and IL-4^-/-/IL-13^-/- mice at day 5 of gestation were plotted on a histogram for comparison.