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Figure 7


Fig. 7. The early heart gene network regulates heart differentiation and migration. Mesp expression initiates heart specification in the B7.5 lineage. Mesp is thought to upregulate Ets1/2 expression in the whole B7.5 lineage. An FGF signal activates Ets1/2 in the anterior B7.5 cells, thus inducing both heart muscle specification and cell migration. Activated Ets1/2 activates process-specific genes for both heart differentiation (the heart-kernel genes) and cell migration (FoxF) in parallel pathways. Mesp presumably functions in parallel to Ets1/2 to regulate GATA-a, NK-4 and FoxF expression. FoxF and activated Ets1/2 function in parallel to control heart cell migration.