Fig. 4. TEAD4 is required for the formation of a blastocoel cavity, but not through regulation of cadherin 1 (Cdh1). (A) E3.5 embryos were treated as in Fig. 3, except that they were immunostained with anti-CDH1 antibody (green). (B) Schematic representation of the relationship between transcription factor TEAD4 and other genes and events in the establishment of the trophectoderm lineage. Upward and downward pointing arrows indicate increased and decreased expression, respectively.