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Figure 11


Fig. 11. Model of role of PDGF signaling in opV trigeminal placode induction. Secreted PDGF ligand from the neural folds is necessary for opV trigeminal placode induction at st. 8. By st. 10, many opV trigeminal placode cells are specified (Pax3+ in green). By st. 13-14, opV trigeminal placode cells begin to delaminate and condense to form regions of the opV trigeminal ganglion, expressing Pax3 (green), Hu and NF (red). TGP, opV trigeminal placode; TG, opV trigeminal ganglion.