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Figure 4


Fig. 4. Filopodial matching occurs during healing of a wound in the ventral epithelium. Images from Movie 5 (see Movie 5 in the supplementary material) showing healing of a wound across an en stripe in the epithelium of an en-RFP-Moesin (red), ptc-GFP-Moesin (green) Drosophila embryo. (A-A'') Filopodia are produced by wound edge cells. (B-C'') Interactions occur between ptc-GFP-Moesin cells across the wound. (D-E'') Eventually a filopodial tether forms between en-RFP-Moesin cells on either side of the wound and this tether rapidly leads to fusion of the two en cells. Notably, the last part of the wound to heal is at the junction between en and ptc cells. The described filopodial interactions are indicated by arrowheads. Scale bar: 10 µm.