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Figure 10


Fig. 10. Models of the roles of Dia in actin and Myosin regulation. (A) Cell biological model of actin-myosin regulation at AJs by Dia. Dia induces formation of actin-myosin cables at AJs, leading to AJ stabilization either directly or/and by blocking access of endocytic machinery to AJ proteins. In the absence of Dia, AJs are destabilized and Myosin activity outside AJs stimulates cell protrusiveness. (B) Mechanistic model of coordinated actin and Myosin regulation by the Rho pathway.