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Figure 2


Fig. 2. Forced expression of epithelial β-catenin leads to precocious hair follicle induction. (A-L) Detection of placodes in control (A-C,G-I) and Catnb{Delta}ex3K14/+ skin (D-F,J-L) by in situ hybridization at E12.5 (A,D,G,J), E13 (B,E,H,K) and E13.5 (C,F,I,L) using Wnt10b (A-F) and Edar (G-L) as markers. In the Catnb{Delta}ex3K14/+ mutants, first hair placode-like structures have already appeared at E12.5 (insets in D and J). Insets (A,D,G,J) are higher magnifications of the boxed areas in the shoulder region of E12.5 skin. (M-O) Whole-mount X-gal staining for E11, E12.5 and E13 Rosa26;K14Cre mice showing the Cre recombinase activity. Arrowheads indicate mammary placodes. L, limb. Arrows indicate Cre activity in shoulder region. Scale bars: 2 mm.