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Development, Vol 100, Issue 1 13-22, Copyright © 1987 by Company of Biologists

JOURNAL ARTICLES

The galactose-specific receptor system in rat liver during development

L Dini, L Conti-Devirgiliis and S Russo-Caia
Department of Biology, University of Rome, Tor Vergata, Italy.

The number and distribution of galactose-specific binding sites were investigated in rat liver cells during perinatal development. Ligand binding to hepatocytes, macrophages and endothelial cells was followed with in vitro and in situ experiments by electron microscopy, using lactosylated bovine serum albumin adsorbed onto 5 nm colloidal gold particles as ligand. Binding capacity, starting at a late stage of fetal development, is very low both on the hepatocyte and on the macrophage surface, which show single particles statistically distributed. By contrast, bound particles are absent from fetal endothelial cells, which also lack the typical coated regions. In vivo, experiments at 37 degrees C show that endocytosis occurs to some extent in prenatal life. These results indicate that the expression of galactose-specific receptors' activity on the different liver cell types follows different developmental patterns, which are independently modulated.


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© The Company of Biologists Ltd 1987