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Development, Vol 100, Issue 4 745-755, Copyright © 1987 by Company of Biologists
JOURNAL ARTICLES |
KA Jermyn, M Berks, RR Kay and JG Williams
Imperial Cancer Research Fund, Clare Hall Laboratories, Herts, UK.
We have isolated cDNA clones derived from three mRNA sequences which are inducible by DIF, the putative stalk-specific morphogen of Dictyostelium. The three mRNA sequences are selectively expressed in cells on the stalk cell pathway of differentiation and we have compared them with previously characterized prestalk-enriched mRNA sequences. We find these latter sequences are expressed without a dependence on DIF, are much less highly enriched in prestalk over prespore cells and are expressed earlier during development than the DIF-inducible mRNA sequences. We propose two distinct mechanisms whereby a mRNA may become enriched in prestalk cells. An apparently small number of genes, represented by those we have isolated, is inducible by DIF and accumulates only in prestalk cells. We suggest that a second class of prestalk-enriched mRNA sequences are induced by cAMP to accumulate in all cells during aggregation and then become enriched in prestalk cells by selective loss from prespore cells.
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J M Louis, G T Ginsburg, and A R Kimmel The cAMP receptor CAR4 regulates axial patterning and cellular differentiation during late development of Dictyostelium. Genes & Dev., September 1, 1994; 8(17): 2086 - 2096. [Abstract] [PDF]
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J L Dynes, A M Clark, G Shaulsky, A Kuspa, W F Loomis, and R A Firtel LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium. Genes & Dev., April 15, 1994; 8(8): 948 - 958. [Abstract] [PDF]
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G R Schnitzler, W H Fischer, and R A Firtel Cloning and characterization of the G-box binding factor, an essential component of the developmental switch between early and late development in Dictyostelium. Genes & Dev., February 15, 1994; 8(4): 502 - 514. [Abstract] [PDF]
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J A Hadwiger and R A Firtel Analysis of G alpha 4, a G-protein subunit required for multicellular development in Dictyostelium. Genes & Dev., January 1, 1992; 6(1): 38 - 49. [Abstract] [PDF]
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T J Sun and P N Devreotes Gene targeting of the aggregation stage cAMP receptor cAR1 in Dictyostelium. Genes & Dev., April 1, 1991; 5(4): 572 - 582. [Abstract] [PDF]
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R K Esch and R A Firtel cAMP and cell sorting control the spatial expression of a developmentally essential cell-type-specific ras gene in Dictyostelium. Genes & Dev., January 1, 1991; 5(1): 9 - 21. [Abstract] [PDF]
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L Haberstroh and R A Firtel A spatial gradient of expression of a cAMP-regulated prespore cell-type-specific gene in Dictyostelium. Genes & Dev., April 1, 1990; 4(4): 596 - 612. [Abstract] [PDF]
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A L Hjorth, C Pears, J G Williams, and R A Firtel A developmentally regulated trans-acting factor recognizes dissimilar G/C-rich elements controlling a class of cAMP-inducible Dictyostelium genes. Genes & Dev., March 1, 1990; 4(3): 419 - 432. [Abstract] [PDF]
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