|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 102, Issue 2 409-425, Copyright © 1988 by Company of Biologists
JOURNAL ARTICLES |
R Reynolds and GP Wilkin
Department of Biochemistry, Imperial College of Science and Technology, London, UK.
Using immunofluorescence with a panel of antibodies that recognize antigens expressed by oligodendroglia, the myelin-producing cells of the CNS, at different stages of differentiation from precursor to mature cell, we have investigated the development of cells of this lineage in cryostat sections of rat cerebellum. Our results are consistent with the view that glial precursors, identified by their expression of the ganglioside GD3, arise in the subependymal layers of the 4th ventricle and migrate to their final position in the cerebellum via the superior medullary velum, and to some extent the peduncles. As the cells reach their final destination they make the transition to recognizable galactocerebroside (GC)-expressing oligodendroglia, via a GD3+/GC+ intermediate. The myelin-associated protein 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) appears at the same time as GC, whereas myelin basic protein (MBP) is expressed 2-3 days after GC and CNP, immediately prior to myelin formation. A very clear progression of oligodendroglial differentiation was observed from the SMV into the base of the cerebellum, up into the white matter (WM) tracts of the folia, and then away from this central white matter into the granule cell and Purkinje cell layers, and finally the molecular layer. The time delay between the expression of GC, CNP and MBP was the same for oligodendroglia in all of these layers, suggesting the presence of an intrinsic clock controlling the initial expression of these myelin components. The early appearance of CNP in oligodendroglia suggests a role for this protein in the early stages of myelinogenesis.
This article has been cited by other articles:
|
|
 |
|
  A. A. Jarjour, S.-J. Bull, M. Almasieh, S. Rajasekharan, K. A. Baker, J. Mui, J. P. Antel, A. Di Polo, and T. E. Kennedy Maintenance of Axo-Oligodendroglial Paranodal Junctions Requires DCC and Netrin-1 J. Neurosci., October 22, 2008; 28(43): 11003 - 11014. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Nishiyama Polydendrocytes: NG2 Cells with Many Roles in Development and Repair of the CNS Neuroscientist, February 1, 2007; 13(1): 62 - 76. [Abstract] [PDF]
|
|
|
|
 |
|
 L. Collin, A. Usiello, E. Erbs, C. Mathis, and E. Borrelli Motor training compensates for cerebellar dysfunctions caused by oligodendrocyte ablation PNAS, January 6, 2004; 101(1): 325 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Mathis, L. Collin, and E. Borrelli Oligodendrocyte ablation impairs cerebellum development Development, October 1, 2003; 130(19): 4709 - 4718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Bouslama-Oueghlani, R. Wehrle, C. Sotelo, and I. Dusart The Developmental Loss of the Ability of Purkinje Cells to Regenerate Their Axons Occurs in the Absence of Myelin: An In Vitro Model to Prevent Myelination J. Neurosci., September 10, 2003; 23(23): 8318 - 8329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Imitola, E. Y. Snyder, and S. J. Khoury Genetic programs and responses of neural stem/progenitor cells during demyelination: potential insights into repair mechanisms in multiple sclerosis Physiol Genomics, August 15, 2003; 14(3): 171 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gianola, T. Savio, M. E. Schwab, and F. Rossi Cell-Autonomous Mechanisms and Myelin-Associated Factors Contribute to the Development of Purkinje Axon Intracortical Plexus in the Rat Cerebellum J. Neurosci., June 1, 2003; 23(11): 4613 - 4624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Huber, O. Weinmann, C. Brosamle, T. Oertle, and M. E. Schwab Patterns of Nogo mRNA and Protein Expression in the Developing and Adult Rat and After CNS Lesions J. Neurosci., May 1, 2002; 22(9): 3553 - 3567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Calza, M. Fernandez, A. Giuliani, L. Aloe, and L. Giardino Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis PNAS, February 20, 2002; (2002) 52704499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Ghiani and V. Gallo Inhibition of Cyclin E-Cyclin-Dependent Kinase 2 Complex Formation and Activity Is Associated with Cell Cycle Arrest and Withdrawal in Oligodendrocyte Progenitor Cells J. Neurosci., February 15, 2001; 21(4): 1274 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Wolswijk Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis Brain, January 1, 2000; 123(1): 105 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Niehaus, J. Stegmuller, M. Diers-Fenger, and J. Trotter Cell-Surface Glycoprotein of Oligodendrocyte Progenitors Involved in Migration J. Neurosci., June 15, 1999; 19(12): 4948 - 4961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Chandross, R. I. Cohen, P. Paras Jr, M. Gravel, P. E. Braun, and L. D. Hudson Identification and Characterization of Early Glial Progenitors Using a Transgenic Selection Strategy J. Neurosci., January 15, 1999; 19(2): 759 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P Casaccia-Bonnefil, R. Hardy, K. Teng, J. Levine, A Koff, and M. Chao Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation Development, January 9, 1999; 126(18): 4027 - 4037. [Abstract] [PDF]
|
|
|
|
|
|
C. Ghiani, A. Eisen, X Yuan, R. DePinho, C. McBain, and V Gallo Neurotransmitter receptor activation triggers p27(Kip1 )and p21(CIP1) accumulation and G1 cell cycle arrest in oligodendrocyte progenitors Development, January 2, 1999; 126(5): 1077 - 1090. [Abstract] [PDF]
|
|
|
|
|
|
X Yuan, A. Eisen, C. McBain, and V Gallo A role for glutamate and its receptors in the regulation of oligodendrocyte development in cerebellar tissue slices Development, January 8, 1998; 125(15): 2901 - 2914. [Abstract] [PDF]
|
|
|
|
|
|
S.-i. Sakakibara and H. Okano Expression of Neural RNA-Binding Proteins in the Postnatal CNS: Implications of Their Roles in Neuronal and Glial Cell Development J. Neurosci., November 1, 1997; 17(21): 8300 - 8312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Dusart, M. S. Airaksinen, and C. Sotelo Purkinje Cell Survival and Axonal Regeneration Are Age Dependent: An In Vitro Study J. Neurosci., May 15, 1997; 17(10): 3710 - 3726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hardy and V. Friedrich Oligodendrocyte progenitors are generated throughout the embryonic mouse brain, but differentiate in restricted foci Development, January 7, 1996; 122(7): 2059 - 2069. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Louis, E Magal, S Takayama, and S Varon CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death Science, January 29, 1993; 259(5095): 689 - 692. [Abstract] [PDF]
|
|
|
|
|
|
H. Mudhar, R. Pollock, C Wang, C. Stiles, and W. Richardson PDGF and its receptors in the developing rodent retina and optic nerve Development, January 6, 1993; 118(2): 539 - 552. [Abstract] [PDF]
|
|
|
|
|
|
N. Pringle and W. Richardson A singularity of PDGF alpha-receptor expression in the dorsoventral axis of the neural tube may define the origin of the oligodendrocyte lineage Development, January 2, 1993; 117(2): 525 - 533. [Abstract] [PDF]
|
|
|
|
|
|
L. Calza, M. Fernandez, A. Giuliani, L. Aloe, and L. Giardino Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis PNAS, March 5, 2002; 99(5): 3258 - 3263. [Abstract] [Full Text] [PDF]
|
|
