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Development, Vol 102, Issue 4 853-867, Copyright © 1988 by Company of Biologists

JOURNAL ARTICLES

Retinoic acid alters EGF receptor expression during palatogenesis

BD Abbott, ED Adamson and RM Pratt
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.

Various growth factors are necessary for normal embryonic development and EGF receptors are present in developing palatal shelves of embryonic/fetal mice at least from day 12 of gestation. The medial epithelium of the palatal shelf undergoes a series of developmental events which do not occur in the oral and nasal epithelia. In utero and in organ culture, the control palatal medial epithelium shows a developmental decline in EGF receptors, demonstrated both by a decrease in the binding of antibody to EGF receptors and a decrease in the binding of 125I-EGF; decreases which are not observed in cells of the adjacent oral or nasal epithelium. During this period, medial cells cease DNA synthesis and undergo programmed cell death. Medial epithelial cells exposed to all-trans-retinoic acid continue to express EGF receptors, bind EGF, proliferate, fail to undergo programmed cell death and exhibit a morphology typical of nasal cells. The data suggest that this disturbance by retinoic acid of EGF receptor localization and subsequent alterations in differentiation of the epithelial cells plays a role in the retinoic-acid-mediated induction of cleft palate.


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D Sun, C. Vanderburg, G. Odierna, and E. Hay
TGFbeta3 promotes transformation of chicken palate medial edge epithelium to mesenchyme in vitro
Development, January 1, 1998; 125(1): 95 - 105.
[Abstract] [PDF]


© The Company of Biologists Ltd 1988