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Development, Vol 103, Issue 2 345-351, Copyright © 1988 by Company of Biologists

JOURNAL ARTICLES

Adenosine induces dormancy in starfish blastulae

N Tsuchimori, S Miyashiro, H Shibai and S Ikegami
Department of Applied Biochemistry, Hiroshima University, Japan.

External application of 50 micrograms ml-1 adenosine inhibits development of the starfish Asterina pectinifera at the 256-cell stage when all the embryonic cells differentiate to epithelial cells. Intracellular concentration of adenosine in the adenosine-treated embryo is 2.7 times higher than those of the normal embryo whereas the contents of ATP, ADP, AMP and adenosine 3',5'-monophosphate are the same for both embryos. Adenosine causes more than 95% reduction in the rate of protein, DNA and RNA syntheses. By returning the embryo to normal sea water, macromolecular synthesis restarts and the embryo develops to the bipinnaria stage.




© The Company of Biologists Ltd 1988