|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 103, Issue 3 497-506, Copyright © 1988 by Company of Biologists
JOURNAL ARTICLES |
F Stylianopoulou, A Efstratiadis, J Herbert and J Pintar
Department of Genetics and Development, Columbia University, New York, NY 10032.
The rat insulin-like growth factor II (IGF-II) gene, encoding a fetal somatomedin, expresses a family of transcripts in embryonic/fetal tissues, and also in the adult choroid plexus and the leptomeninges. We have localized IGF-II gene transcripts in sections of rat embryos of embryonic days 10-16 by performing in situ hybridization. These transcripts are present in the head mesenchyme, formed from both the mesoderm and the cephalic portion of the neural crest, and also in the majority of other tissues of mesodermal origin, predominantly those derived from the somites and the lateral mesoderm. Intense labelling was detected in muscle cells, and their precursors, throughout the examined stages, whereas in chondrocytes the initial high level of hybridization declined substantially prior to ossification. IGF-II gene transcripts are also present in derivatives of other germ layers, but in restricted sites. Thus, from the derivatives of the endoderm, only the liver and the bronchial epithelium yielded hybridization signals. Ectoderm-derived tissues, including the central and peripheral nervous system, were negative for hybridization, with the exception of the choroid plexus, the newly forming pituitary rudiment and, to a lesser extent, the auditory placode. The pattern of IGF-II gene expression during embryogenesis overlaps significantly with the reported distribution of immunohistochemically detected TGF-beta 1. A paracrine/autocrine role for IGF-II in the developmental process is discussed.
This article has been cited by other articles:
|
|
 |
|
  K. A. Sullivan, B. Kim, and E. L. Feldman Insulin-Like Growth Factors in the Peripheral Nervous System Endocrinology, December 1, 2008; 149(12): 5963 - 5971. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. P. Kovacheva, T. J. Mellott, J. M. Davison, N. Wagner, I. Lopez-Coviella, A. C. Schnitzler, and J. K. Blusztajn Gestational Choline Deficiency Causes Global and Igf2 Gene DNA Hypermethylation by Up-regulation of Dnmt1 Expression J. Biol. Chem., October 26, 2007; 282(43): 31777 - 31788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Silva, M. Venihaki, W.-H. Guo, and M. F. Lopez Igf2 Deficiency Results in Delayed Lung Development at the End of Gestation Endocrinology, December 1, 2006; 147(12): 5584 - 5591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. K Bale and C. A Conover Disruption of insulin-like growth factor-II imprinting during embryonic development rescues the dwarf phenotype of mice null for pregnancy-associated plasma protein-A J. Endocrinol., August 1, 2005; 186(2): 325 - 331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Conover, L. K. Bale, M. T. Overgaard, E. W. Johnstone, U. H. Laursen, E.-M. Fuchtbauer, C. Oxvig, and J. van Deursen Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development Development, March 1, 2004; 131(5): 1187 - 1194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sato, M. Nakamura, D. H. Cho, S. J. Tapscott, H. Ozaki, and K. Kawakami Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1 Hum. Mol. Genet., May 1, 2002; 11(9): 1045 - 1058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ishihara, N. Hatano, H. Furuumi, R. Kato, T. Iwaki, K. Miura, Y. Jinno, and H. Sasaki Comparative Genomic Sequencing Identifies Novel Tissue-Specific Enhancers and Sequence Elements for Methylation-Sensitive Factors Implicated in Igf2/H19 Imprinting Genome Res., May 1, 2000; 10(5): 664 - 671. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Nielsen, J. Christiansen, J. Lykke-Andersen, A. H. Johnsen, U. M. Wewer, and F. C. Nielsen A Family of Insulin-Like Growth Factor II mRNA-Binding Proteins Represses Translation in Late Development Mol. Cell. Biol., February 1, 1999; 19(2): 1262 - 1270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. REHFELD The New Biology of Gastrointestinal Hormones Physiol Rev, October 1, 1998; 78(4): 1087 - 1108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ainscough, T Koide, M Tada, S Barton, and M. Surani Imprinting of Igf2 and H19 from a 130 kb YAC transgene Development, January 9, 1997; 124(18): 3621 - 3632. [Abstract] [PDF]
|
|
|
|
 |
|
 C. A. Eisenberg and D. M. Bader Establishment of the Mesodermal Cell Line QCE-6 : A Model System for Cardiac Cell Differentiation Circ. Res., February 1, 1996; 78(2): 205 - 216. [Abstract] [Full Text]
|
|
|
|
|
|
L. Rossetti, N. Barzilai, W. Chen, T. Harris, D. Yang, and C. E. Rogler Hepatic Overexpression of Insulin-like Growth Factor-II in Adulthood Increases Basal and Insulin-stimulated Glucose Disposal in Conscious Mice J. Biol. Chem., January 5, 1996; 271(1): 203 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Sasaki, A. Ferguson-Smith, A. Shum, S. Barton, and M. Surani Temporal and spatial regulation of H19 imprinting in normal and uniparental mouse embryos Development, January 12, 1995; 121(12): 4195 - 4202. [Abstract] [PDF]
|
|
|
|
|
|
M. Cusella-De Angelis, S Molinari, A Le Donne, M Coletta, E Vivarelli, M Bouche, M Molinaro, S Ferrari, and G Cossu Differential response of embryonic and fetal myoblasts to TGF beta: a possible regulatory mechanism of skeletal muscle histogenesis Development, January 4, 1994; 120(4): 925 - 933. [Abstract] [PDF]
|
|
|
|
|
|
R Ohlsson, F Hedborg, L Holmgren, C Walsh, and T. Ekstrom Overlapping patterns of IGF2 and H19 expression during human development: biallelic IGF2 expression correlates with a lack of H19 expression Development, January 2, 1994; 120(2): 361 - 368. [Abstract] [PDF]
|
|
|
|
 |
|
 D A Rappolee, K S Sturm, O Behrendtsen, G A Schultz, R A Pedersen, and Z Werb Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos. Genes & Dev., June 1, 1992; 6(6): 939 - 952. [Abstract] [PDF]
|
|
|
|
|
|
E. Jagerbauer, A Fraser, E. Herbst, R Kothary, and R Fundele Parthenogenetic stem cells in postnatal mouse chimeras Development, January 9, 1992; 116(1): 95 - 102. [Abstract] [PDF]
|
|
