|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 103, Issue 4 785-790, Copyright © 1988 by Company of Biologists
JOURNAL ARTICLES |
GH Schmidt, DJ Winton and BA Ponder
Department of Cell Biology, Fraunhofer-Institute, Hannover, FRG.
We have previously shown that the epithelium of each adult intestinal crypt in chimaeric mice is derived from a single progenitor cell. Whether the crypts are monoclonal from the outset-that is, are formed by the proliferation of a single cell-or whether their formation is initiated by several cells was not known. Here we report that many crypts contain cells of both chimaeric genotypes in the neonatal period indicating a polyclonal origin at this stage of morphogenesis. The cellular organization of the early neonatal crypt is therefore different from that of the adult crypt, which includes a zone of 'anchored' stem cells above the crypt base. Within 2 weeks, however, the crypt progenitor cell and its descendants displace all other cells from the crypt and the crypt attains monoclonality. The distribution of enterocytes on chimaeric villi in the neonate shows a mottled pattern of mosaicism which is progressively replaced by coherent sheets of cells from the crypts, and within two weeks the orderly adult clonal pattern is established.
This article has been cited by other articles:
|
|
 |
|
  M. J. Geske, X. Zhang, K. K. Patel, D. M. Ornitz, and T. S. Stappenbeck Fgf9 signaling regulates small intestinal elongation and mesenchymal development Development, September 1, 2008; 135(17): 2959 - 2968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Barker, M. van de Wetering, and H. Clevers The intestinal stem cell Genes & Dev., July 15, 2008; 22(14): 1856 - 1864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Takano-Maruyama, K. Hase, H. Fukamachi, Y. Kato, H. Koseki, and H. Ohno Foxl1-deficient mice exhibit aberrant epithelial cell positioning resulting from dysregulated EphB/EphrinB expression in the small intestine Am J Physiol Gastrointest Liver Physiol, July 1, 2006; 291(1): G163 - G170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Z. Rizvi, J. R. Swain, P. S. Davies, A. S. Bailey, A. D. Decker, H. Willenbring, M. Grompe, W. H. Fleming, and M. H. Wong Bone marrow-derived cells fuse with normal and transformed intestinal stem cells PNAS, April 18, 2006; 103(16): 6321 - 6325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, T. S. Stappenbeck, A. C. White, K. J. Lavine, J. I. Gordon, and D. M. Ornitz Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development Development, January 1, 2006; 133(1): 173 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Bettess, N. Dubois, M. J. Murphy, C. Dubey, C. Roger, S. Robine, and A. Trumpp c-Myc Is Required for the Formation of Intestinal Crypts but Dispensable for Homeostasis of the Adult Intestinal Epithelium Mol. Cell. Biol., September 1, 2005; 25(17): 7868 - 7878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Thliveris, R. B. Halberg, L. Clipson, W. F. Dove, R. Sullivan, M. K. Washington, S. Stanhope, and M. A. Newton From the Cover: Polyclonality of familial murine adenomas: Analyses of mouse chimeras with low tumor multiplicity suggest short-range interactions PNAS, May 10, 2005; 102(19): 6960 - 6965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Radtke and H. Clevers Self-Renewal and Cancer of the Gut: Two Sides of a Coin Science, March 25, 2005; 307(5717): 1904 - 1909. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhang, K. T. Ebata, and M. C. Nagano Genetic Analysis of the Clonal Origin of Regenerating Mouse Spermatogenesis Following Transplantation Biol Reprod, December 1, 2003; 69(6): 1872 - 1878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. R. Bennett, T. E. Crew, J. M. W. Slack, and A. Ward Structural-proliferative units and organ growth: effects of insulin-like growth factor 2 on the growth of colon and skin Development, March 15, 2003; 130(6): 1079 - 1088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Stappenbeck, L. V. Hooper, and J. I. Gordon Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells PNAS, November 26, 2002; 99(24): 15451 - 15455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Sherley Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture Stem Cells, November 1, 2002; 20(6): 561 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Wong, J. Huelsken, W. Birchmeier, and J. I. Gordon Selection of Multipotent Stem Cells during Morphogenesis of Small Intestinal Crypts of Lieberkuhn Is Perturbed by Stimulation of Lef-1/beta -Catenin Signaling J. Biol. Chem., May 3, 2002; 277(18): 15843 - 15850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yatabe, S. Tavare, and D. Shibata Investigating stem cells in human colon by using methylation patterns PNAS, August 21, 2001; (2001) 191225998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Stappenbeck and J. I. Gordon Extranuclear sequestration of phospho-Jun N-terminal kinase and distorted villi produced by activated Rac1 in the intestinal epithelium of chimeric mice Development, July 1, 2001; 128(13): 2603 - 2614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ameen, Y Figueroa, and P. Salas Anomalous apical plasma membrane phenotype in CK8-deficient mice indicates a novel role for intermediate filaments in the polarization of simple epithelia J. Cell Sci., January 2, 2001; 114(3): 563 - 575. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Pacha Development of Intestinal Transport Function in Mammals Physiol Rev, October 1, 2000; 80(4): 1633 - 1667. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Bach, A. G. Renehan, and C. S. Potten Stem cells: the intestinal stem cell as a paradigm Carcinogenesis, March 1, 2000; 21(3): 469 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Slack Stem Cells in Epithelial Tissues Science, February 25, 2000; 287(5457): 1431 - 1433. [Abstract] [Full Text]
|
|
|
|
|
|
T. Stappenbeck and J. Gordon Rac1 mutations produce aberrant epithelial differentiation in the developing and adult mouse small intestine Development, January 6, 2000; 127(12): 2629 - 2642. [Abstract] [PDF]
|
|
|
|
|
|
M. R. Novelli, H. Wasan, I. Rosewell, J. Bee, I. P. Tomlinson, N. A. Wright, and W. F. Bodmer Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras PNAS, October 26, 1999; 96(22): 12553 - 12558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Slorach, F. Campbell, and J. Dorin A mouse model of intestinal stem cell function and regeneration J. Cell Sci., January 9, 1999; 112(18): 3029 - 3038. [Abstract] [PDF]
|
|
|
|
|
|
C Bierkamp, H Schwarz, O Huber, and R Kemler Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice Development, January 1, 1999; 126(2): 371 - 381. [Abstract] [PDF]
|
|
|
|
 |
|
 N. Barker, G. Huls, V. Korinek, and H. Clevers Restricted High Level Expression of Tcf-4 Protein in Intestinal and Mammary Gland Epithelium Am. J. Pathol., January 1, 1999; 154(1): 29 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G. Falk, L. V. Hooper, T. Midtvedt, and J. I. Gordon Creating and Maintaining the Gastrointestinal Ecosystem: What We Know and Need To Know from Gnotobiology Microbiol. Mol. Biol. Rev., December 1, 1998; 62(4): 1157 - 1170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Nomura, M Kaminishi, K Sugiyama, T Oohara, and H Esumi Clonal analysis of isolated intestinal metaplastic glands of stomach using X linked polymorphism Gut, May 1, 1998; 42(5): 663 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Merritt, K. A. Gould, and W. F. Dove Polyclonal structure of intestinal adenomas in ApcMin/+ mice with concomitant loss of Apc+ from all tumor lineages PNAS, December 9, 1997; 94(25): 13927 - 13931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Garabedian, L. J. J. Roberts, M. S. McNevin, and J. I. Gordon Examining the Role of Paneth Cells in the Small Intestine by Lineage Ablation in Transgenic Mice J. Biol. Chem., September 19, 1997; 272(38): 23729 - 23740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M L Hermiston, M H Wong, and J I Gordon Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system. Genes & Dev., April 15, 1996; 10(8): 985 - 996. [Abstract] [PDF]
|
|
|
|
|
|
M. L. Hermiston and J. I. Gordon Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin Science, November 17, 1995; 270(5239): 1203 - 1207. [Abstract] [PDF]
|
|
|
|
|
|
E. Jagerbauer, A Fraser, E. Herbst, R Kothary, and R Fundele Parthenogenetic stem cells in postnatal mouse chimeras Development, January 9, 1992; 116(1): 95 - 102. [Abstract] [PDF]
|
|
|
|
|
|
Y. Yatabe, S. Tavare, and D. Shibata From the Cover: Investigating stem cells in human colon by using methylation patterns PNAS, September 11, 2001; 98(19): 10839 - 10844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Wong, J. R. Saam, T. S. Stappenbeck, C. H. Rexer, and J. I. Gordon Genetic mosaic analysis based on Cre recombinase and navigated laser capture microdissection PNAS, November 7, 2000; 97(23): 12601 - 12606. [Abstract] [Full Text] [PDF]
|
|
