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Development, Vol 104, Issue 1 29-39, Copyright © 1988 by Company of Biologists

JOURNAL ARTICLES

Histochemical localization of IGF-I and IGF-II mRNA in the rat between birth and adulthood

F Beck, NJ Samani, S Byrne, K Morgan, R Gebhard and WJ Brammar
Department of Anatomy, University of Leicester, UK.

We describe the postnatal ontogeny and localization of insulin-like growth factors I and II (IGF-I and -II) in the rat. We have used oligodeoxyribonucleotide probes for in situ hybridization (hybridization histochemistry) and for Northern blotting. IGF-II mRNA is strongly expressed in liver, skeletal muscle, perichondrium, leptomeninges and choroid plexus of the newborn. Demonstrable levels fall dramatically in the liver at 18-20 days postnatally but persist for longer periods in muscle and remain undiminished throughout life in the pia/choroid plexus, indicating that different control mechanisms operate in these tissues. IGF-I mRNA is predominantly found in the liver. Its level in this organ rises well before levels of IGF-II fall. This suggests that distinct factors govern the expression of IGF-I and -II genes.


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© The Company of Biologists Ltd 1988