|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 104, Issue 3 495-509, Copyright © 1988 by Company of Biologists
JOURNAL ARTICLES |
PT Merrill, D Sweeton and E Wieschaus
Department of Biology, Princeton University, NJ 08540.
To identify early requirements for zygotic gene activity in Drosophila, we used compound autosomes and autosome-Y translocations to generate embryos deficient for cytologically defined portions of the genome. No obvious gross morphological defects were observed in any deficiency class until the beginning of cycle 14. Only seven autosomal regions were identified with discrete effects visible prior to the onset of gastrulation. These regions include genes with locus-specific effects on the clearing of the cortical cytoplasm during early cycle 14, (22AB), the initiation of the slow and fast phases of cellularization (26BF and 40AC, respectively), the apical-basal distribution of nuclei during cycle 14 (71C-75C) and the closing off of furrow canals during cellularization (100AC). The distal tip of the third chromosome also contains two loci (99DF and 100AC) whose deletion causes multiple nuclei to be cellularized into single cells, a phenotype similar to that produced in embryos totally lacking the X-chromosome.
This article has been cited by other articles:
|
|
 |
|
  J. R. Bateman and C.-t. Wu A Genomewide Survey Argues That Every Zygotic Gene Product Is Dispensable for the Initiation of Somatic Homolog Pairing in Drosophila Genetics, November 1, 2008; 180(3): 1329 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pisarev, E. Poustelnikova, M. Samsonova, and J. Reinitz FlyEx, the quantitative atlas on segmentation gene expression at cellular resolution Nucleic Acids Res., October 25, 2008; (2008) gkn717v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Monzo, O. Papoulas, G. T. Cantin, Y. Wang, J. R. Yates III, and J. C. Sisson Fragile X mental retardation protein controls trailer hitch expression and cleavage furrow formation in Drosophila embryos PNAS, November 28, 2006; 103(48): 18160 - 18165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Schneider, N. Najand, S. Chaker, J. M. Pare, J. Haskins, S. C. Hughes, T. C. Hobman, J. Locke, and A. J. Simmonds Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development J. Cell Biol., July 31, 2006; 174(3): 349 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Pilot, J.-M. Philippe, C. Lemmers, J.-P. Chauvin, and T. Lecuit Developmental control of nuclear morphogenesis and anchoring by charleston, identified in a functional genomic screen of Drosophila cellularisation Development, February 15, 2006; 133(4): 711 - 723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Jaeger, M. Blagov, D. Kosman, K. N. Kozlov, Manu, E. Myasnikova, S. Surkova, C. E. Vanario-Alonso, M. Samsonova, D. H. Sharp, et al. Dynamical Analysis of Regulatory Interactions in the Gap Gene System of Drosophila melanogaster Genetics, August 1, 2004; 167(4): 1721 - 1737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ryder, F. Blows, M. Ashburner, R. Bautista-Llacer, D. Coulson, J. Drummond, J. Webster, D. Gubb, N. Gunton, G. Johnson, et al. The DrosDel Collection: A Set of P-Element Insertions for Generating Custom Chromosomal Aberrations in Drosophila melanogaster Genetics, June 1, 2004; 167(2): 797 - 813. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Royou, C. Field, J. C. Sisson, W. Sullivan, and R. Karess Reassessing the Role and Dynamics of Nonmuscle Myosin II during Furrow Formation in Early Drosophila Embryos Mol. Biol. Cell, February 1, 2004; 15(2): 838 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Stein, H. T. Broihier, L. A. Moore, and R. Lehmann Slow as Molasses is required for polarized membrane growth and germ cell migration in Drosophila Development, March 10, 2003; 129(16): 3925 - 3934. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Lanzotti, H. Kaygun, X. Yang, R. J. Duronio, and W. F. Marzluff Developmental Control of Histone mRNA and dSLBP Synthesis during Drosophila Embryogenesis and the Role of dSLBP in Histone mRNA 3' End Processing In Vivo Mol. Cell. Biol., April 1, 2002; 22(7): 2267 - 2282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Blankenship and E. Wieschaus Two new roles for the Drosophila AP patterning system in early morphogenesis Development, December 15, 2001; 128(24): 5129 - 5138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Hari, K. R. Cook, and G. H. Karpen The Drosophila Su(var)2-10 locus regulates chromosome structure and function and encodes a member of the PIAS protein family Genes & Dev., June 1, 2001; 15(11): 1334 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sugimoto, A. Kusano, R. R. Hozak, W. B. Derry, J. Zhu, and J. H. Rothman Many Genomic Regions Are Required for Normal Embryonic Programmed Cell Death in Caenorhabditis elegans Genetics, May 1, 2001; 158(1): 237 - 252. [Abstract] [Full Text]
|
|
|
|
|
|
A. Tang, T. Neufeld, G. Rubin, and H. Muller Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian Development, January 3, 2001; 128(5): 801 - 813. [Abstract] [PDF]
|
|
|
|
|
|
J. E. Tomkiel, B. T. Wakimoto, and A. Briscoe , Jr. The teflon Gene Is Required for Maintenance of Autosomal Homolog Pairing at Meiosis I in Male Drosophila melanogaster Genetics, January 1, 2001; 157(1): 273 - 281. [Abstract] [Full Text]
|
|
|
|
|
|
A. Wodarz, A. Ramrath, A. Grimm, and E. Knust Drosophila Atypical Protein Kinase C Associates with Bazooka and Controls Polarity of Epithelia and Neuroblasts J. Cell Biol., September 18, 2000; 150(6): 1361 - 1374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Lecuit and E. Wieschaus Polarized Insertion of New Membrane from a Cytoplasmic Reservoir during Cleavage of the Drosophila Embryo J. Cell Biol., August 21, 2000; 150(4): 849 - 860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. X. Zhang, W. F. Rothwell, W. Sullivan, and T.-s. Hsieh Discontinuous Actin Hexagon, a Protein Essential for Cortical Furrow Formation in Drosophila, Is Membrane Associated and Hyperphosphorylated Mol. Biol. Cell, March 1, 2000; 11(3): 1011 - 1022. [Abstract] [Full Text]
|
|
|
|
 |
|
 W. Rothwell, C. Zhang, C Zelano, T. Hsieh, and W Sullivan The Drosophila centrosomal protein Nuf is required for recruiting Dah, a membrane associated protein, to furrows in the early embryo J. Cell Sci., January 9, 1999; 112(17): 2885 - 2893. [Abstract] [PDF]
|
|
|
|
|
|
H Muller, R Samanta, and E Wieschaus Wingless signaling in the Drosophila embryo: zygotic requirements and the role of the frizzled genes Development, January 2, 1999; 126(3): 577 - 586. [Abstract] [PDF]
|
|
|
|
|
|
B. de Saint Phalle and W. Sullivan Spindle Assembly and Mitosis without Centrosomes in Parthenogenetic Sciara Embryos J. Cell Biol., June 15, 1998; 141(6): 1383 - 1391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R J Duronio and P H O'Farrell Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F. Genes & Dev., June 15, 1995; 9(12): 1456 - 1468. [Abstract] [PDF]
|
|
|
|
|
|
M. A. Postner and E. F. Wieschaus The nullo protein is a component of the actin-myosin network that mediates cellularization in Drosophila melanogaster embryos J. Cell Sci., July 1, 1994; 107(7): 1863 - 1873. [Abstract] [PDF]
|
|
|
|
|
|
K. Irvine and E Wieschaus Cell intercalation during Drosophila germband extension and its regulation by pair-rule segmentation genes Development, January 4, 1994; 120(4): 827 - 841. [Abstract] [PDF]
|
|
|
|
|
|
W Sullivan, P Fogarty, and W Theurkauf Mutations affecting the cytoskeletal organization of syncytial Drosophila embryos Development, January 8, 1993; 118(4): 1245 - 1254. [Abstract] [PDF]
|
|
|
|
|
|
S Govind, L Brennan, and R Steward Homeostatic balance between dorsal and cactus proteins in the Drosophila embryo Development, January 1, 1993; 117(1): 135 - 148. [Abstract] [PDF]
|
|
|
|
|
|
L S Rose and E Wieschaus The Drosophila cellularization gene nullo produces a blastoderm-specific transcript whose levels respond to the nucleocytoplasmic ratio. Genes & Dev., July 1, 1992; 6(7): 1255 - 1268. [Abstract] [PDF]
|
|
|
|
 |
|
 L Chen, M Krause, B Draper, H Weintraub, and A Fire Body-wall muscle formation in Caenorhabditis elegans embryos that lack the MyoD homolog hlh-1 Science, April 10, 1992; 256(5054): 240 - 243. [Abstract] [PDF]
|
|
|
|
 |
|
 E.D. Schejter, L.S. Rose, M.A. Postner, and E. Wieschaus Role of the Zygotic Genome in the Restructuring of the Actin Cytoskeleton at the Cycle-14 Transition during Drosophila Embryogenesis Cold Spring Harb Symp Quant Biol, January 1, 1992; 57(0): 653 - 659. [Abstract] [PDF]
|
|
|
|
|
|
C H Girdham and D M Glover Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein. Genes & Dev., October 1, 1991; 5(10): 1786 - 1799. [Abstract] [PDF]
|
|
|
|
|
|
F Schweisguth, J A Lepesant, and A Vincent The serendipity alpha gene encodes a membrane-associated protein required for the cellularization of the Drosophila embryo. Genes & Dev., June 1, 1990; 4(6): 922 - 931. [Abstract] [PDF]
|
|
|
|
|
|
C. Hunter, P. Sung, E. D. Schejter, and E. Wieschaus Conserved Domains of the Nullo Protein Required for Cell-Surface Localization and Formation of Adherens Junctions Mol. Biol. Cell, January 1, 2002; 13(1): 146 - 157. [Abstract] [Full Text] [PDF]
|
|
