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Mesoderm-inducing activity can be extracted from eggs or whole ovary. It binds to heparin and can be heparin or anti-bFGF but not by anti-TGFbeta. Two be identified by Western blotting and have molecular 19 and 14K. The content in embryos is about 7unitsg-1 7ngml-1) which would be sufficient for it to be acting inducer of ventral mesoderm. Attempts to detect
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T. Lamb and R. Harland Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern Development, January 11, 1995; 121(11): 3627 - 3636. [Abstract] [PDF]
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R. Cornell, T. Musci, and D Kimelman FGF is a prospective competence factor for early activin-type signals in Xenopus mesoderm induction Development, January 8, 1995; 121(8): 2429 - 2437. [Abstract] [PDF]
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 D. Kessler and D. Melton Vertebrate embryonic induction: mesodermal and neural patterning Science, October 28, 1994; 266(5185): 596 - 604. [Abstract] [PDF]
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D. Shi, V Fromentoux, C Launay, M Umbhauer, and J. Boucaut Isolation and developmental expression of the amphibian homolog of the fibroblast growth factor receptor 3 J. Cell Sci., January 3, 1994; 107(3): 417 - 425. [Abstract] [PDF]
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R. Cornell and D Kimelman Activin-mediated mesoderm induction requires FGF Development, January 2, 1994; 120(2): 453 - 462. [Abstract] [PDF]
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M. Kengaku and H. Okamoto Basic fibroblast growth factor induces differentiation of neural tube and neural crest lineages of cultured ectoderm cells from Xenopus gastrula Development, December 1, 1993; 119(4): 1067 - 1078. [Abstract] [PDF]
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 G von Dassow, J E Schmidt, and D Kimelman Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene. Genes & Dev., March 1, 1993; 7(3): 355 - 366. [Abstract] [PDF]
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D. du Cros, K Isaacs, and G. Moore Distribution of acidic and basic fibroblast growth factors in ovine skin during follicle morphogenesis J. Cell Sci., January 7, 1993; 105(3): 667 - 674. [Abstract] [PDF]
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R. Albano, N Groome, and J. Smith Activins are expressed in preimplantation mouse embryos and in ES and EC cells and are regulated on their differentiation Development, January 2, 1993; 117(2): 711 - 723. [Abstract] [PDF]
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H L Sive The frog prince-ss: a molecular formula for dorsoventral patterning in Xenopus. Genes & Dev., January 1, 1993; 7(1): 1 - 12. [PDF]
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D. E. Smith, F. Franco del Amo, and T. Gridley Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development Development, December 1, 1992; 116(4): 1033 - 1039. [Abstract] [PDF]
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R. Friesel and S. A. Brown Spatially restricted expression of fibroblast growth factor receptor-2 during Xenopus development Development, December 1, 1992; 116(4): 1051 - 1058. [Abstract] [PDF]
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D. Kimelman, J. L. Christian, and R. T. Moon Synergistic principles of development: overlapping patterning systems in Xenopus mesoderm induction Development, September 1, 1992; 116(1): 1 - 9. [Abstract] [PDF]
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J. Maslanski, L Leshko, and W. Busa Lithium-sensitive production of inositol phosphates during amphibian embryonic mesoderm induction Science, April 10, 1992; 256(5054): 243 - 245. [Abstract] [PDF]
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M Umbhauer, J. Riou, J Spring, J. Smith, and J. Boucaut Expression of tenascin mRNA in mesoderm during Xenopus laevis embryogenesis: the potential role of mesoderm patterning in tenascin regionalization Development, January 9, 1992; 116(1): 147 - 157. [Abstract] [PDF]
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D. Shi, J. Feige, J. Riou, D. DeSimone, and J. Boucaut Differential expression and regulation of two distinct fibroblast growth factor receptors during early development of the urodele amphibian Pleurodeles waltl Development, January 9, 1992; 116(1): 261 - 273. [Abstract] [PDF]
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J. Saint-Jeannet, G Levi, J. Girault, V Koteliansky, and J. Thiery Ventrolateral regionalization of Xenopus laevis mesoderm is characterized by the expression of alpha-smooth muscle actin Development, January 8, 1992; 115(4): 1165 - 1173. [Abstract] [PDF]
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D. Melton Pattern formation during animal development Science, April 12, 1991; 252(5003): 234 - 241. [Abstract] [PDF]
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K W Cho and E M De Robertis Differential activation of Xenopus homeo box genes by mesoderm-inducing growth factors and retinoic acid. Genes & Dev., November 1, 1990; 4(11): 1910 - 1916. [Abstract] [PDF]
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M Gabbianelli, M Sargiacomo, E Pelosi, U Testa, G Isacchi, and C Peschle "Pure" human hematopoietic progenitors: permissive action of basic fibroblast growth factor Science, September 28, 1990; 249(4976): 1561 - 1564. [Abstract] [PDF]
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S Sokol, G. Wong, and D. Melton A mouse macrophage factor induces head structures and organizes a body axis in Xenopus Science, August 3, 1990; 249(4968): 561 - 564. [Abstract] [PDF]
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