spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tyson, J. J.
Right arrow Articles by Murray, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tyson, J. J.
Right arrow Articles by Murray, J. D.

Development, Vol 106, Issue 3 421-426, Copyright © 1989 by Company of Biologists

JOURNAL ARTICLES

Cyclic AMP waves during aggregation of Dictyostelium amoebae

JJ Tyson and JD Murray
Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061.

During the aggregation phase of their life cycle, Dictyostelium discoideum amoebae communicate with each other by traveling waves of cyclic AMP. These waves are generated by an interplay between random diffusion of cyclic AMP in the extracellular milieu and the signal-reception/signal/relaying capabilities of individual amoebae. Kinetic properties of the enzymes, transport proteins and cell-surface receptor proteins involved in the cyclic AMP signaling system have been painstakingly worked out over the past fifteen years in many laboratories. Recently Martiel & Goldbeter (1987) incorporated this biochemical information into a unified mathematical model of communication among Dictyostelium amoebae. Numerical simulations of the mathematical model, carried out by Tyson et al. (1989), agree in quantitative detail with experimental observations of cyclic AMP traveling waves in Dictyostelium cultures. Such mathematical modeling and numerical experimentation provide a necessary link between detailed studies of the molecular control mechanism and experimental observations of the intact developmental system.


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Lauzeral, J. Halloy, and A. Goldbeter
Desynchronization of cells on the developmental path triggers the formation of spiral waves of cAMP during Dictyostelium aggregation
PNAS, August 19, 1997; 94(17): 9153 - 9158.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1989